Data Details
Disease Name liver cirrhosis
Tissue liver
Database GEO
Data ID GSE98618
Data Type sequence
Platform GPL18900
Species homo sapiens
Sample Number 56
PubMed ID 28843658
Title Trunk events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma [multinodular CNV]
Data Description "Paraffin-embedded and fresh-frozen samples representing early steps of hepatocarcinogenesis were collected and gDNA was extracted. This cohort comprised: 29 dysplastic nodules (DN) -including low-grade and high-grade dysplasia (LGDN and HGDN)-; and 17 small tumors (sHCCs) -including 6 very-early and 11 early HCCs (veHCC and eHCC). When available matched cirrhotic tissues was also collected and extracted. Comparative Genomic Hybridization analysis was done using HumanOmniExpress-24 v1.1 BeadChip (Illumina) according to manufacturer's protocols. Previous treatment with the Infinium FFPE restoration kit (Illumina) was performed for FFPE samples. Log R ratio (LRR, reflecting total copy number) and B-allele frequency (BAF) obtained from GenomeStudio were used for CNV detection."
Keyword cirrhosis gDNA
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